Collageneer®, a patented active ingredient derived from Lupin seed coatings, has the ability not only to increase the synthesis of type I collagen (the most abundant collagen, which diminishes with age), but also to promote production of a high quality collagen that gives the skin its firmness and elasticity.
1. Effect on type I collagen synthesis
(human fibroblasts, 72-hour treatment, ELISA test)
Lupeol significantly stimulates production and secretion of type I collagen, starting at 7 mg/ml, via overexpression of the collagen la1 (qRT-PCR: +46% pour 20 µg/ml).
2. Effect on HSP47
(human fibroblasts, 48-hour treatment, Western blot test) Lupeol induces overproduction of HSP47, a type I collagen molecular chaperone, via overexpression of the gene (qRT-PCR: +21% pour 20µg/ml).
HSP47 assists in the correct assembly of the triple helix (chaperone function) and helps prevent maturation of abnormal procollagen (quality control function).
(25 volunteers, 89 days, 2% active ingredient, 2 applications/day) This open study was carried out to validate the concept on volunteers.
1. Skin elasticity (Cutometer)
Beginning at T42, an increase in the parameters Ur/Ue and Ur/Uf is noted, corresponding to an improvement in skin elasticity. At T89, the increases—of 11.2% and 10.6%, respectively—are significant.
2. Facial contour (fringe projection)
With age, the skin of the facial oval sags and increases in volume. At T42, a significant reduction in this volume is seen.
This is confirmed and amplified at T89.
3. Self-assessment
The volunteers confirmed these clinical results by their own assessment of the cream's effectiveness:
Improved firmness of the skin 92%
Reduced sagging of the facial contour 72%
CHARACTERS -------------------------------- Oily and limpid liquid, with yellow to brown-orange colour and a characteristic odor
TOTAL LUPEOL CONTENT --------------- 3.5 to 4.5g/100g
ALPHA-TOCOPHEROL CONTENT ----- 50mg/100g
COLLAGENEER® contains no preservatives
STORAGE: Under nitrogen, in a hermetically sealed container, protected from light and humidity, between 15 and 25°c.
COLLAGENEER® is intended for cosmetic use (topical administration).
