Reinforcement of the barrier function and soothing action for dry, mature or reactive skin.
Soline® is capable of stimulating the synthesis of key lipids by the keratinocytes (ex vivo test **). These lipids are therefore directly present in situ, and wholly available to perform their role and contribute effectively to reinforcing the
barrier function of the epidermis.
A cream containing 2% of active ingredient was applied to skin explants (18h incubation at 37°C). An increase in
ceramides 1 and 2 and cerebrosides was observed, with no change in the quantity of total lipids.
Soline® reduces the quantity of
inflammation mediators (cytokines) in the presence of an aggressive chemical agent (PMA) or UV radiation (in vitro tests). The production of these mediators is also regulated by the key transcription factor NF_B.
In vitro, stimulation of the keratinocytes induces activation of NFkB, which leads to increased fluorescence in the nuclei (translocation). Treatment with 0.0002% Soline significantly inhibits activation of NFkB (36%).
These results therefore demonstrate the modulating effect of Soline® Bio on the inflammatory cascade from the PPARα receptor, through transcription factor NFkB, to the mediators.
20 volunteers with
dry to scaly skin tested a cream containing 2% of active ingredient.
1 - After a single application:
- There was an immediate increase in
moisturisation (corneometer): +48.6% moisturisation 1 hour after application, and the efficacy is lasting, as the increase is +34.2% after 24 hours.
2 - After 4 weeks (applied twice daily):
- The microrelief and surface appearance were evaluated with biopsies conducted before and after the study. Restructuring of the network of micro-depressions, and a 52% improvement in surface appearance, were observed.
- The appearance of the skin was also evaluated by scores given by the volunteers and the study director. The dryness, roughness and
desquamation parameters significantly improved after 4 weeks.
Soline® is an oily active ingredient rich in unsaponifiable molecules. Small amounts of these molecules are naturally present in sunflower seed oil, and they are classed as noble molecules in view of their properties.
Using a physical (solvent-free) process called "molecular distillation", the unsaponifiable fraction of the oil is concentrated to obtain the oil distillate, which is then deodorised.
